申論題

7. While the plasma membrane is a dynamic fluid, its lipid composition is highly asymmetrical. Discuss the physiological significance of Phosphatidylinositol (PI) and its phosphorylated derivatives being sequestered specifically in the inner (cytoplasmic) leaflet ofthe membrane bilayer. In your answer, explain how this localization facilitates the PLC-mediated signaling pathway and analyze the consequences for cellular signaling if this asymmetry were lost.