試題詳解

36. PARP inhibitors can efficiently kill many breast cancer cells that lack functional Brcal or Brca2 genes. How do these drugs accomplish this?

(1) By increasing the occurrences of homologous recombination.

(2) By increasing the ability of the cancer cells to repair the mutations in their cancer-critical genes. 

(3) By inhibiting a DNA repair pathway.

(4) By increasing the ability of p53 in cancer cells to limit cell proliferation. 

(5) By inhibiting proteins that are normally inhibited by the Brcal or Brca2 gene products.
(A) (1) only.
(B) (1), (4), (5).
(C) (3) only.
(D) (2), (3), (4), (5).
(E) All of the above are correct.