試題詳解

24. What is the primary mechanism by which pyroptosis is executed following cleavage of Gasdermin D (GSDMD) by inflammatory caspases?
(A) The GSDMD N-terminal fragment oligomerizes and forms pores in the plasma membrane.
(B) The GSDMD N-terminal fragment binds to and permeabilizes the mitochondrial outer membrane, releasing cytochrome c.
(C) The GSDMD N-terminal fragment directly activates the kinase RIPK3 to initiate a secondary death signal.
(D) The GSDMD N-terminal fragment translocates to the nucleus to induce pro-inflammatory gene expression.
(E) The GSDMD is degraded by caspases.